GW29-e1601 Ghrelin partially protects against heart failure after myocardial infarction by increasing the Bcl-2/Bax ratio in a GHS-R1a-dependent manner
نویسندگان
چکیده
منابع مشابه
Acute heart failure after myocardial infarction.
We compared two groups of patients after acute myocardial infarction. First group was treated with fibrinolytics and they were hospitalized within six hours from the beginning of the first chest-symptoms, and second group that did not come within optimal time was treated with anticoagulants only. The patients were classified according to Killip-classification, shock-index and TIMI-risk-score af...
متن کاملPrevention of Heart Failure after Myocardial Infarction
Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and is frequently associated with metabolic risk factors. Patients with HFpEF have only a slightly lower mortality than patients with HF and reduced EF. The pathophysiology of HFpEF is currently incompletely understood, which precludes specific therapy. Both HF phenotypes demonstrate distinct cardiac remodeling processes...
متن کاملHeart failure after acute myocardial infarction: a lost battle in the war on heart failure?
Improvements in the treatment of acute myocardial infarction (AMI), especially use of reperfusion therapy, have led to larger numbers of survivors. In patients who would have survived despite reperfusion therapy, use of this treatment should lead to greater myocardial salvage and a reduced extent of ventricular injury in many. However, others who might not have survived previously may now do so...
متن کاملProgression of heart failure after myocardial infarction in the rat.
This study examined the early neurohumoral events in the progression of congestive heart failure (CHF) after myocardial infarction (MI) in rats. Immediately after MI was induced by coronary artery ligation, rats had severely depressed left ventricular systolic function and increased left ventricular end-diastolic volume (LVEDV). Both left ventricular function and the neurohumoral indicators of ...
متن کاملTicagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction.
OBJECTIVE In addition to P2Y12 receptor antagonism, ticagrelor inhibits adenosine cell uptake. Prior data show that 7-day pretreatment with ticagrelor limits infarct size. We explored the acute effects of ticagrelor and clopidogrel on infarct size and potential long-term effects on heart function. APPROACH AND RESULTS Rats underwent 30-minute ischemia per 24-hour reperfusion. (1) Ticagrelor (...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2018
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2018.08.181